Tetrahydrofuran → 5-[({1-[3-(1-Methylethyl)-1,2,4-oxadiazol-5-yl]-4-piperidinyl}methyl)oxy]-2-[4-(methylsulfonyl)phenyl]pyrimidine

HRID 1217729Notes

Reaction equation

HRID 1217729 reaction equation
[CH2:67]1[O:68][CH2:69][CH2:70][CH2:71]1.[CH3:18][CH:19]([CH3:20])[c:21]1[n:22][o:23][c:24]([N:26]2[CH2:27][CH2:28][CH:29]([CH2:32][OH:33])[CH2:30][CH2:31]2)[n:25]1.[CH3:1][S:2](=[O:3])(=[O:4])[c:5]1[cH:6][cH:7][c:8](-[c:11]2[n:12][cH:13][c:14]([OH:17])[cH:15][n:16]2)[cH:9][cH:10]1.[O:53]=[C:54]([O:55][CH:56]([CH3:57])[CH3:58])[N:59]=[N:60][C:61]([O:62][CH:63]([CH3:64])[CH3:65])=[O:66].[c:34]1([P:35]([c:36]2[cH:37][cH:38][cH:39][cH:40][cH:41]2)[c:42]2[cH:43][cH:44][cH:45][cH:46][cH:47]2)[cH:48][cH:49][cH:50][cH:51][cH:52]1>>[CH3:1][S:2](=[O:3])(=[O:4])[c:5]1[cH:6][cH:7][c:8](-[c:11]2[n:12][cH:13][c:14]([O:17][CH2:32][CH:29]3[CH2:28][CH2:27][N:26]([c:24]4[o:23][n:22][c:21]([CH:19]([CH3:18])[CH3:20])[n:25]4)[CH2:31][CH2:30]3)[cH:15][n:16]2)[cH:9][cH:10]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 11776TriphenylphosphineHCID 75555Diisopropyl diazene-1,2-dicarboxylateHCID 57930076{1-[3-(1-Methylethyl)-1,2,4-oxadiazol-5-yl]-4-piperidinyl}methanolHCID 666730022-(4-(Methylsulfonyl)phenyl)pyrimidin-5-ol

Product 1

HCID 249934075-[({1-[3-(1-Methylethyl)-1,2,4-oxadiazol-5-yl]-4-piperidinyl}methyl)oxy]-2-[4-(methylsulfonyl)phenyl]pyrimidine

Sources & evidence

ORD record
ord-65107229ebc6492994574c7760e91215
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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