Potassium Cation → Methyl 4-bromo-5-(trifluoromethyl)thiophene-2-carboxylate

HRID 1218355Notes

Reaction equation

HRID 1218355 reaction equation
[Br:1][c:2]1[cH:3][c:4]([C:8](=[O:9])[O:10][CH3:11])[s:5][c:6]1[I:7].[CH3:30][N:31]([CH3:32])[P:33]([N:34]([CH3:35])[CH3:36])([N:37]([CH3:38])[CH3:39])=[O:40].[Cu:41][I:42].[F-:12].[F:14][C:15]([S:16]([F:17])(=[O:18])=[O:19])([C:20]([O:21][CH3:22])=[O:23])[F:24].[K+:13].[O:25]=[CH:26][N:27]([CH3:28])[CH3:29]>>[Br:1][c:2]1[cH:3][c:4]([C:8](=[O:9])[O:10][CH3:11])[s:5][c:6]1[C:15]([F:12])([F:14])[F:24]

Participants

8

Reactant 7

HCID 813Potassium CationHCID 6228DimethylformamideHCID 12679HexamethylphosphoramideHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 28179Fluoride IonHCID 547667Methyl 2,2-difluoro-2-(fluorosulfonyl)acetateHCID 57826852Methyl 4-bromo-5-iodothiophene-2-carboxylate

Product 1

HCID 57826561Methyl 4-bromo-5-(trifluoromethyl)thiophene-2-carboxylate

Sources & evidence

ORD record
ord-2b8bcce2dc324936a601044d31b5d124
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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