Tetrahydrofuran → 3,5-Dichloro-N-(3-(N-(3,5-dichlorobenzyl)-N-(4-fluorobenzyl)sulfamoyl)benzyl)-N-(4-fluorobenzyl)-2-hydroxybenzenesulfonamide

HRID 1218471Notes

Reaction equation

HRID 1218471 reaction equation
[CH2:63]1[O:64][CH2:65][CH2:66][CH2:67]1.[CH3:51][CH2:52][N:53]([CH2:54][CH3:55])[CH2:56][CH3:57].[Cl:1][c:2]1[cH:3][c:4]([CH2:5][N:6]([S:7](=[O:8])(=[O:9])[c:10]2[cH:11][c:12]([CH2:16][NH:17][CH2:18][c:19]3[cH:20][cH:21][c:22]([F:25])[cH:23][cH:24]3)[cH:13][cH:14][cH:15]2)[CH2:26][c:27]2[cH:28][cH:29][c:30]([F:33])[cH:31][cH:32]2)[cH:34][c:35]([Cl:37])[cH:36]1.[Cl:38][c:39]1[c:40]([OH:50])[c:41]([S:46](=[O:47])(=[O:48])[Cl:49])[cH:42][c:43]([Cl:45])[cH:44]1.[S:58]([Cl:59])([Cl:60])(=[O:61])=[O:62]>>[Cl:1][c:2]1[cH:3][c:4]([CH2:5][N:6]([S:7](=[O:8])(=[O:9])[c:10]2[cH:11][c:12]([CH2:16][N:17]([CH2:18][c:19]3[cH:20][cH:21][c:22]([F:25])[cH:23][cH:24]3)[S:46]([c:41]3[c:40]([OH:50])[c:39]([Cl:38])[cH:44][c:43]([Cl:45])[cH:42]3)(=[O:47])=[O:48])[cH:13][cH:14][cH:15]2)[CH2:26][c:27]2[cH:28][cH:29][c:30]([F:33])[cH:31][cH:32]2)[cH:34][c:35]([Cl:37])[cH:36]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 24648Sulfuryl chlorideHCID 900783,5-Dichloro-2-hydroxybenzenesulphonyl chlorideHCID 58531573N-(3,5-Dichlorobenzyl)-N-(4-fluorobenzyl)-3-((4-fluorobenzylamino)methyl)benzenesulfonamide

Product 1

HCID 585314823,5-Dichloro-N-(3-(N-(3,5-dichlorobenzyl)-N-(4-fluorobenzyl)sulfamoyl)benzyl)-N-(4-fluorobenzyl)-2-hydroxybenzenesulfonamide

Sources & evidence

ORD record
ord-1609aff3586e4cd8b994bdc1530fbedb
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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