Methanol → Trifluoroacetic acid

HRID 1218505Notes

Reaction equation

HRID 1218505 reaction equation
[CH3:37][C:38]([Cl:39])=[O:40].[CH3:46][OH:47].[F:1][C:2]([C:3](=[O:4])[OH:5])([F:6])[F:7].[NH2:8][c:9]1[n:10][cH:11][cH:12][c:13](-[c:15]2[c:16](-[c:24]3[cH:25][cH:26][c:27]([F:30])[cH:28][cH:29]3)[c:17]3[c:18]([n:19][cH:20][cH:21][n:22]3)[nH:23]2)[cH:14]1.[O:41]1[CH2:42][CH2:43][CH2:44][CH2:45]1.[cH:31]1[cH:32][cH:33][n:34][cH:35][cH:36]1>>[F:1][C:2]([C:3](=[O:4])[OH:5])([F:6])[F:7].[NH:8]([c:9]1[n:10][cH:11][cH:12][c:13](-[c:15]2[c:16](-[c:24]3[cH:25][cH:26][c:27]([F:30])[cH:28][cH:29]3)[c:17]3[c:18]([n:19][cH:20][cH:21][n:22]3)[nH:23]2)[cH:14]1)[C:38]([CH3:37])=[O:40]

Participants

8

Reactant 6

HCID 887MethanolHCID 1049PyridineHCID 6367Acetyl chlorideHCID 6422Trifluoroacetic acidHCID 8028TetrahydrofuranHCID 22987994HCID 22987994, compound

Product 2

HCID 6422Trifluoroacetic acidHCID 12109314HCID 12109314, compound

Sources & evidence

ORD record
ord-c2987d5b2f02472da1c7d29951007ff4
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

Loading…