Tetrahydrofuran → 5-((3,5-Difluorophenyl)(hydroxy)methyl)-2-fluorobenzonitrile
Reaction equation
[Br:2][c:3]1[cH:4][c:5]([F:10])[cH:6][c:7]([F:9])[cH:8]1.[F:11][c:12]1[c:13]([C:14]#[N:15])[cH:16][c:17]([CH:20]=[O:21])[cH:18][cH:19]1.[Mg:1].[O:22]1[CH2:23][CH2:24][CH2:25][CH2:26]1>>[c:3]1([CH:20]([c:17]2[cH:16][c:13]([C:14]#[N:15])[c:12]([F:11])[cH:19][cH:18]2)[OH:21])[cH:4][c:5]([F:10])[cH:6][c:7]([F:9])[cH:8]1Participants
5
Sources & evidence
- ORD record
- ord-94c8d94c8cde45b3b4d26a06db0ae771
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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