Carbon Dioxide → 1-(3,5-difluorophenyl)-2-(6-carboxymethyl-2,3-dihydro-4-oxo-5-phenyl-4H-1,3-oxazin-3-yl)-2-methylpropan-1-one

HRID 1218688Notes

Reaction equation

HRID 1218688 reaction equation
[CH3:1][Si:2]([N-:3][Si:4]([CH3:5])([CH3:6])[CH3:7])([CH3:8])[CH3:9].[F:11][c:12]1[cH:13][c:14]([C:19]([C:20]([CH3:21])([CH3:22])[N:23]2[CH2:24][O:25][C:26]([CH3:36])=[C:27]([c:30]3[cH:31][cH:32][cH:33][cH:34][cH:35]3)[C:28]2=[O:29])=[O:37])[cH:15][c:16]([F:18])[cH:17]1.[Li+:10].[O:38]=[C:39]=[O:40].[O:41]1[CH2:42][CH2:43][CH2:44][CH2:45]1>>[F:11][c:12]1[cH:13][c:14]([C:19]([C:20]([CH3:21])([CH3:22])[N:23]2[CH2:24][O:25][C:26]([CH2:36][C:39](=[O:38])[OH:40])=[C:27]([c:30]3[cH:31][cH:32][cH:33][cH:34][cH:35]3)[C:28]2=[O:29])=[O:37])[cH:15][c:16]([F:18])[cH:17]1

Participants

6

Reactant 5

HCID 280Carbon DioxideHCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 3280088Npc316347HCID 221182601-(3,5-difluorophenyl)-2-(2,3-dihydro-6-methyl-4-oxo-5-phenyl-4H-1,3-oxazin-3-yl)-2-methyl-propan-1-one

Product 1

HCID 221183161-(3,5-difluorophenyl)-2-(6-carboxymethyl-2,3-dihydro-4-oxo-5-phenyl-4H-1,3-oxazin-3-yl)-2-methylpropan-1-one

Sources & evidence

ORD record
ord-e02d2db56f40473e85c4caf3b6482001
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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