Tetrahydrofuran → 1'-(diphenylmethyl)-6-fluoro-5-methoxyspiro[1-benzofuran-3,3'-indol]-2'(1'H)-one

HRID 1218708Notes

Reaction equation

HRID 1218708 reaction equation
[C:37](=[O:38])([O-:39])[O-:40].[Cl:34][CH2:35][I:36].[Cs+:41].[Cs+:42].[O:43]1[CH2:44][CH2:45][CH2:46][CH2:47]1.[c:1]1([CH:7]([N:8]2[C:9](=[O:27])[CH:10]([c:17]3[c:18]([OH:26])[cH:19][c:20]([F:25])[c:21]([O:23][CH3:24])[cH:22]3)[c:11]3[cH:12][cH:13][cH:14][cH:15][c:16]32)[c:28]2[cH:29][cH:30][cH:31][cH:32][cH:33]2)[cH:2][cH:3][cH:4][cH:5][cH:6]1>>[c:1]1([CH:7]([N:8]2[C:9](=[O:27])[C:10]3([c:11]4[cH:12][cH:13][cH:14][cH:15][c:16]42)[c:17]2[c:18]([cH:19][c:20]([F:25])[c:21]([O:23][CH3:24])[cH:22]2)[O:26][CH2:35]3)[c:28]2[cH:29][cH:30][cH:31][cH:32][cH:33]2)[cH:2][cH:3][cH:4][cH:5][cH:6]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 11644ChloroiodomethaneHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 673773961-(diphenylmethyl)-3-(4-fluoro-2-hydroxy-5-methoxyphenyl)-1,3-dihydro-2H-indol-2-one

Product 1

HCID 673566841'-(diphenylmethyl)-6-fluoro-5-methoxyspiro[1-benzofuran-3,3'-indol]-2'(1'H)-one

Sources & evidence

ORD record
ord-29a18d4dabbd4907a81b7d03a69d5cd5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

Loading…