Hydrochloric Acid → 1-Acetyl-4-[({4-[(3-chloro-2-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}methyl)(methyl)amino]piperidine-4-carboxamide

HRID 1219039Notes

Reaction equation

HRID 1219039 reaction equation
[CH3:1][C:2]([Cl:3])=[O:4].[CH3:39][CH2:40][N:41]([CH2:42][CH3:43])[CH2:44][CH3:45].[Cl:46][CH2:47][Cl:48].[Cl:6][c:7]1[c:8]([F:38])[c:9]([NH:13][c:14]2[n:15][cH:16][n:17][c:18]3[cH:19][c:20]([O:36][CH3:37])[c:21]([CH2:24][N:25]([C:26]4([C:32](=[O:33])[NH2:34])[CH2:27][CH2:28][NH:29][CH2:30][CH2:31]4)[CH3:35])[cH:22][c:23]23)[cH:10][cH:11][cH:12]1.[ClH:5]>>[CH3:1][C:2](=[O:4])[N:29]1[CH2:28][CH2:27][C:26]([N:25]([CH2:24][c:21]2[c:20]([O:36][CH3:37])[cH:19][c:18]3[n:17][cH:16][n:15][c:14]([NH:13][c:9]4[c:8]([F:38])[c:7]([Cl:6])[cH:12][cH:11][cH:10]4)[c:23]3[cH:22]2)[CH3:35])([C:32](=[O:33])[NH2:34])[CH2:31][CH2:30]1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 57979867HCID 57979867, compound

Product 1

HCID 579798211-Acetyl-4-[({4-[(3-chloro-2-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}methyl)(methyl)amino]piperidine-4-carboxamide

Sources & evidence

ORD record
ord-95c70b5291bd4eaca6405ce403359c27
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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