Ammonium → 1-(benzo[d][1,3]dioxol-5-yl)-N-(6-(2-methoxybenzyl)pyridin-3-yl)cyclopropanecarboxamide

HRID 121946Notes

Reaction equation

HRID 121946 reaction equation
[CH2:36]1[O:37][CH2:38][CH2:39][CH2:40]1.[CH3:2][O:3][c:4]1[c:5]([CH2:6][Zn+:7])[cH:8][cH:9][cH:10][cH:11]1.[Cl-:1].[Cl-:34].[NH4+:35].[O:12]1[CH2:13][O:14][c:15]2[c:16]1[cH:17][cH:18][c:19]([C:21]1([C:24](=[O:25])[NH:26][c:27]3[cH:28][n:29][c:30]([Br:33])[cH:31][cH:32]3)[CH2:22][CH2:23]1)[cH:20]2>>[CH3:2][O:3][c:4]1[c:5]([CH2:6][c:30]2[n:29][cH:28][c:27]([NH:26][C:24]([C:21]3([c:19]4[cH:18][cH:17][c:16]5[c:15]([cH:20]4)[O:14][CH2:13][O:12]5)[CH2:22][CH2:23]3)=[O:25])[cH:32][cH:31]2)[cH:8][cH:9][cH:10][cH:11]1

Participants

6

Reactant 5

HCID 223AmmoniumHCID 312Chloride2×HCID 8028TetrahydrofuranHCID 578561131-(benzo[d][1,3]dioxol-5-yl)-N-(6-bromopyridin-3-yl)cyclopropanecarboxamideHCID 178489473HCID 178489473, compound

Product 1

HCID 442063271-(benzo[d][1,3]dioxol-5-yl)-N-(6-(2-methoxybenzyl)pyridin-3-yl)cyclopropanecarboxamide

Sources & evidence

ORD record
ord-5913ea61a7f442b4b5e2fc615dc9ea07
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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