Dimethylformamide → N-Cyclopropyl-4'-(5-{[(3,3-dimethylbutanoyl)amino]methyl}-1,3,4-oxadiazol-2-yl)-6-methyl-1,1'-biphenyl-3-carboxamide

HRID 1219747Notes

Reaction equation

HRID 1219747 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[CH2:5][C:6](=[O:7])[OH:8].[CH:43]([N:44]([CH2:45][CH3:46])[CH:47]([CH3:48])[CH3:49])([CH3:50])[CH3:51].[NH2:52][CH2:53][c:54]1[n:55][n:56][c:57](-[c:59]2[cH:60][cH:61][c:62](-[c:65]3[cH:66][c:67]([C:72](=[O:73])[NH:74][CH:75]4[CH2:76][CH2:77]4)[cH:68][cH:69][c:70]3[CH3:71])[cH:63][cH:64]2)[o:58]1.[O:78]=[CH:79][N:80]([CH3:81])[CH3:82].[OH:33][n:34]1[c:35]2[c:36]([cH:37][cH:38][cH:39][cH:40]2)[n:41][n:42]1.[P-:9]([F:10])([F:11])([F:12])([F:13])([F:14])[F:15].[n:16]1([O:17][C:18]([N:19]([CH3:20])[CH3:21])=[N+:22]([CH3:23])[CH3:24])[c:25]2[n:26][cH:27][cH:28][cH:29][c:30]2[n:31][n:32]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[CH2:5][C:6](=[O:8])[NH:52][CH2:53][c:54]1[n:55][n:56][c:57](-[c:59]2[cH:60][cH:61][c:62](-[c:65]3[cH:66][c:67]([C:72](=[O:73])[NH:74][CH:75]4[CH2:76][CH2:77]4)[cH:68][cH:69][c:70]3[CH3:71])[cH:63][cH:64]2)[o:58]1

Participants

8

Reactant 7

HCID 6228DimethylformamideHCID 9886HexafluorophosphateHCID 14057tert-Butylacetic acidHCID 757711-HydroxybenzotriazoleHCID 81531DiisopropylethylamineHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 99978914'-[5-(aminomethyl)-1,3,4-oxadiazol-2-yl]-N-cyclopropyl-6-methyl-1,1'-biphenyl-3-carboxamide

Product 1

HCID 10003708N-Cyclopropyl-4'-(5-{[(3,3-dimethylbutanoyl)amino]methyl}-1,3,4-oxadiazol-2-yl)-6-methyl-1,1'-biphenyl-3-carboxamide

Sources & evidence

ORD record
ord-5736774ce2a74d8ab62e728da348cc8e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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