Tetrahydrofuran → N-[4-[4-(phenylmethyl)-1-piperazinyl]phenyl]-[1,1'-biphenyl]-2-carboxamide

HRID 1220152Notes

Reaction equation

HRID 1220152 reaction equation
[CH2:36]1[O:37][CH2:38][CH2:39][CH2:40]1.[CH3:41][CH2:42][N:43]([CH2:44][CH3:45])[CH2:46][CH3:47].[c:1]1([CH2:7][N:8]2[CH2:9][CH2:10][N:11]([c:14]3[cH:15][cH:16][c:17]([NH2:20])[cH:18][cH:19]3)[CH2:12][CH2:13]2)[cH:2][cH:3][cH:4][cH:5][cH:6]1.[c:21]1(-[c:30]2[cH:31][cH:32][cH:33][cH:34][cH:35]2)[c:22]([C:27](=[O:28])[Cl:29])[cH:23][cH:24][cH:25][cH:26]1>>[c:1]1([CH2:7][N:8]2[CH2:9][CH2:10][N:11]([c:14]3[cH:15][cH:16][c:17]([NH:20][C:27]([c:22]4[c:21](-[c:30]5[cH:31][cH:32][cH:33][cH:34][cH:35]5)[cH:26][cH:25][cH:24][cH:23]4)=[O:28])[cH:18][cH:19]3)[CH2:12][CH2:13]2)[cH:2][cH:3][cH:4][cH:5][cH:6]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 7372594-(4-Benzylpiperazin-1-yl)anilineHCID 12563768[1,1'-Biphenyl]-2-carbonyl chloride

Product 1

HCID 22499373N-[4-[4-(phenylmethyl)-1-piperazinyl]phenyl]-[1,1'-biphenyl]-2-carboxamide

Sources & evidence

ORD record
ord-84af89fcdf0a4782ac18eb37c07ec21b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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