Hydrochloric Acid → 6-bromo-2-(4-methanesulfonylbenzyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic Acid N-methoxy-N-methylamide

HRID 1220788Notes

Reaction equation

HRID 1220788 reaction equation
[Br:1][c:2]1[cH:3][c:4]2[c:5](-[c:27]3[cH:28][cH:29][cH:30][cH:31][cH:32]3)[c:6]([C:24](=[O:25])[Cl:26])[n:7]([CH2:13][c:14]3[cH:15][cH:16][c:17]([S:20](=[O:21])(=[O:22])[CH3:23])[cH:18][cH:19]3)[c:8](=[O:12])[c:9]2[cH:10][cH:11]1.[CH2:45]([Cl:46])[Cl:47].[CH3:34][NH:35][O:36][CH3:37].[CH3:38][CH2:39][N:40]([CH2:41][CH3:42])[CH2:43][CH3:44].[ClH:33]>>[Br:1][c:2]1[cH:3][c:4]2[c:5](-[c:27]3[cH:28][cH:29][cH:30][cH:31][cH:32]3)[c:6]([C:24](=[O:25])[N:35]([CH3:34])[O:36][CH3:37])[n:7]([CH2:13][c:14]3[cH:15][cH:16][c:17]([S:20](=[O:21])(=[O:22])[CH3:23])[cH:18][cH:19]3)[c:8](=[O:12])[c:9]2[cH:10][cH:11]1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 8471TriethylamineHCID 14232N,O-DimethylhydroxylamineHCID 230605586-bromo-2-(4-methanesulfonylbenzyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carbonyl Chloride

Product 1

HCID 865995606-bromo-2-(4-methanesulfonylbenzyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic Acid N-methoxy-N-methylamide

Sources & evidence

ORD record
ord-8b0fd89640794142a718880f1d04fd60
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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