Tetrahydrofuran → 4-(4-Bromo-2-fluoro-phenylamino)-6-chloro-pyridazine-3-carboxylic acid
Reaction equation
[Br:1][c:2]1[cH:3][c:4]([F:9])[c:5]([NH2:8])[cH:6][cH:7]1.[CH2:31]1[O:32][CH2:33][CH2:34][CH2:35]1.[CH3:11][Si:12]([N-:13][Si:14]([CH3:15])([CH3:16])[CH3:17])([CH3:18])[CH3:19].[Cl:20][c:21]1[c:22]([C:28](=[O:29])[OH:30])[n:23][n:24][c:25]([Cl:27])[cH:26]1.[Li+:10]>>[Br:1][c:2]1[cH:3][c:4]([F:9])[c:5]([NH:8][c:21]2[c:22]([C:28](=[O:29])[OH:30])[n:23][n:24][c:25]([Cl:27])[cH:26]2)[cH:6][cH:7]1Participants
6
Sources & evidence
- ORD record
- ord-607049e4db934cf8a22900171299706f
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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