Sulfuric Acid → C-[4-(4-Iodo-phenyl)-1-(3,3,3-trifluoro-propyl)-piperidin-4-yl]-methylamine
Reaction equation
[Al+3:2].[CH2:33]1[O:34][CH2:35][CH2:36][CH2:37]1.[H-:1].[H-:4].[H-:5].[H-:6].[I:12][c:13]1[cH:14][cH:15][c:16]([C:19]2([C:31]#[N:32])[CH2:20][CH2:21][N:22]([CH2:25][CH2:26][C:27]([F:28])([F:29])[F:30])[CH2:23][CH2:24]2)[cH:17][cH:18]1.[Li+:3].[S:7](=[O:8])(=[O:9])([OH:10])[OH:11]>>[I:12][c:13]1[cH:14][cH:15][c:16]([C:19]2([CH2:31][NH2:32])[CH2:20][CH2:21][N:22]([CH2:25][CH2:26][C:27]([F:28])([F:29])[F:30])[CH2:23][CH2:24]2)[cH:17][cH:18]1Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-d78d9a702a4a4df49313f7745e7b0ac4
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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