Tetrahydrofuran → (3-Chloro-7-fluoro-benzo[b]thiophen-2-yl)methanol

HRID 1223485Notes

Reaction equation

HRID 1223485 reaction equation
[Al+3:30].[CH2:35]1[O:36][CH2:37][CH2:38][CH2:39]1.[Cl:15][c:16]1[c:17]2[c:18]([s:19][c:20]1[C:21](=[O:22])[Cl:23])[c:24]([F:28])[cH:25][cH:26][cH:27]2.[Cl:1][c:2]1[c:3]2[cH:4][c:5]([F:6])[cH:7][cH:8][c:9]2[s:10][c:11]1[C:12]([Cl:13])=[O:14].[H-:29].[H-:32].[H-:33].[H-:34].[Li+:31]>>[Cl:15][c:16]1[c:17]2[c:18]([s:19][c:20]1[CH2:21][OH:22])[c:24]([F:28])[cH:25][cH:26][cH:27]2

Participants

7

Reactant 6

HCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 104727Aluminum CationHCID 166653Hydride4×HCID 148724863-Chloro-5-fluorobenzo[b]thiophene-2-carbonyl chlorideHCID 592776183-Chloro-7-fluoro-benzo[b]thiophene-2-carbonyl chloride

Product 1

HCID 59277539(3-Chloro-7-fluoro-benzo[b]thiophen-2-yl)methanol

Sources & evidence

ORD record
ord-c52fc6478f0f49d688103e8b4b283fdb
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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