Dimethyl Sulfoxide → 1-(Benzo[d][1,3]dioxol-5-yl)-N-(2-tert-butyl-1H-indol-5-yl)cyclopropanecarboxamide

HRID 122496Notes

Reaction equation

HRID 122496 reaction equation
[C:21]([CH3:22])([CH3:23])([CH3:24])[c:25]1[nH:26][c:27]2[cH:28][cH:29][c:30]([NH2:34])[cH:31][c:32]2[cH:33]1.[CH3:16][N:17]([CH3:18])[CH:19]=[O:20].[CH3:35][CH2:36][N:37]([CH2:38][CH3:39])[CH2:40][CH3:41].[CH3:49][S:50]([CH3:51])=[O:52].[Cl:46][CH2:47][Cl:48].[O:1]1[CH2:2][O:3][c:4]2[c:5]1[cH:6][cH:7][c:8]([C:10]1([C:13](=[O:14])[OH:15])[CH2:11][CH2:12]1)[cH:9]2.[S:42]([Cl:43])([Cl:44])=[O:45]>>[O:1]1[CH2:2][O:3][c:4]2[c:5]1[cH:6][cH:7][c:8]([C:10]1([C:13](=[O:15])[NH:34][c:30]3[cH:29][cH:28][c:27]4[nH:26][c:25]([C:21]([CH3:22])([CH3:23])[CH3:24])[cH:33][c:32]4[cH:31]3)[CH2:11][CH2:12]1)[cH:9]2

Participants

8

Reactant 7

HCID 679Dimethyl SulfoxideHCID 6228DimethylformamideHCID 6344DichloromethaneHCID 8471TriethylamineHCID 24386Thionyl ChlorideHCID 27609662-tert-butyl-1H-indol-5-amineHCID 143496081-(1,3-Dioxaindan-5-yl)cyclopropane-1-carboxylic acid

Product 1

HCID 247629031-(Benzo[d][1,3]dioxol-5-yl)-N-(2-tert-butyl-1H-indol-5-yl)cyclopropanecarboxamide

Sources & evidence

ORD record
ord-c4cb0c0de25b4d3b9de041dd73b52b45
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

Loading…