Tetrahydrofuran → 1-Carbethoxy-4-hydroxy-4-[2-(4-methylphenylsulfanyl)phenyl]piperidine

HRID 1226397Notes

Reaction equation

HRID 1226397 reaction equation
[C:21](=[O:22])([O:23][CH2:24][CH3:25])[N:26]1[CH2:27][CH2:28][C:29](=[O:32])[CH2:30][CH2:31]1.[CH2:16]([Li:17])[CH2:18][CH2:19][CH3:20].[O:33]1[CH2:34][CH2:35][CH2:36][CH2:37]1.[c:1]1([CH3:15])[cH:2][cH:3][c:4]([S:7][c:8]2[c:9]([Br:14])[cH:10][cH:11][cH:12][cH:13]2)[cH:5][cH:6]1>>[c:1]1([CH3:15])[cH:2][cH:3][c:4]([S:7][c:8]2[c:9]([C:29]3([OH:32])[CH2:28][CH2:27][N:26]([C:21](=[O:22])[O:23][CH2:24][CH3:25])[CH2:31][CH2:30]3)[cH:10][cH:11][cH:12][cH:13]2)[cH:5][cH:6]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 34767Ethyl 4-oxo-1-piperidinecarboxylateHCID 21864904(2-Bromophenyl)(p-tolyl)sulfaneHCID 178418339Butyllithium

Product 1

HCID 452583081-Carbethoxy-4-hydroxy-4-[2-(4-methylphenylsulfanyl)phenyl]piperidine

Sources & evidence

ORD record
ord-b71759f500b04123bd27d6abcaba920a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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