Trifluoroacetic acid → 1-[4-(3-Pyrrolidin-1-ylmethyl-cyclobutyl)-benzyl]-pyrrolidine

HRID 1226634Notes

Reaction equation

HRID 1226634 reaction equation
[CH2:31]([SiH:32]([CH2:33][CH3:34])[CH2:35][CH3:36])[CH3:37].[F:24][C:25]([F:26])([F:27])[C:28]([OH:29])=[O:30].[N:1]1([CH2:6][CH:7]2[CH2:8][C:9]([OH:11])([c:12]3[cH:13][cH:14][c:15]([CH2:18][N:19]4[CH2:20][CH2:21][CH2:22][CH2:23]4)[cH:16][cH:17]3)[CH2:10]2)[CH2:2][CH2:3][CH2:4][CH2:5]1>>[N:1]1([CH2:6][CH:7]2[CH2:8][CH:9]([c:12]3[cH:13][cH:14][c:15]([CH2:18][N:19]4[CH2:20][CH2:21][CH2:22][CH2:23]4)[cH:16][cH:17]3)[CH2:10]2)[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 12052TriethylsilaneHCID 219348323-Pyrrolidin-1-ylmethyl-1-(4-pyrrolidin-1-ylmethyl-phenyl)-cyclobutanol

Product 1

HCID 113125751-[4-(3-Pyrrolidin-1-ylmethyl-cyclobutyl)-benzyl]-pyrrolidine

Sources & evidence

ORD record
ord-1e803888a1a9482ca5e6e29926ebe1a3
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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