Methyl iodide → 6-Methyl-2-(1,1,1-trifluoro-2-methylpropan-2-yl)-5,6,7,8-tetrahydroquinoline-6-carboxylic acid
Reaction equation
[CH2:49]1[O:50][CH2:51][CH2:52][CH2:53]1.[CH3:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26].[CH3:2][CH:3]([N-:4][CH:5]([CH3:6])[CH3:7])[CH3:8].[CH3:47][I:48].[CH:9]([NH:10][CH:11]([CH3:12])[CH3:13])([CH3:14])[CH3:15].[F:27][C:28]([C:29]([CH3:30])([CH3:31])[c:32]1[n:33][c:34]2[c:39]([cH:40][cH:41]1)[CH2:38][CH:37]([C:42](=[O:43])[OH:44])[CH2:36][CH2:35]2)([F:45])[F:46].[Li+:1].[Li:16][CH2:17][CH2:18][CH2:19][CH3:20]>>[CH3:2][C:37]1([C:42](=[O:43])[OH:44])[CH2:36][CH2:35][c:34]2[n:33][c:32]([C:29]([C:28]([F:27])([F:45])[F:46])([CH3:30])[CH3:31])[cH:41][cH:40][c:39]2[CH2:38]1Participants
9
Reactant 8
Product 1
Sources & evidence
- ORD record
- ord-7b7632fb015a4a4eb888ba115761cdd5
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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