Tetrahydrofuran → 1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)-2-fluorophenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea
Reaction equation
[CH2:62]1[O:63][CH2:64][CH2:65][CH2:66]1.[CH3:1][O:2][c:3]1[cH:4][c:5]2[c:6]([O:15][c:16]3[c:17]([F:23])[c:18]([NH2:19])[cH:20][cH:21][cH:22]3)[n:7][cH:8][n:9][c:10]2[cH:11][c:12]1[O:13][CH3:14].[CH3:67][N:68]([CH3:69])[c:70]1[cH:71][cH:72][n:73][cH:74][cH:75]1.[F:24][C:25]([C:26]([CH3:27])([CH3:28])[c:29]1[cH:30][c:31]([NH:34][C:35]([O:36][c:38]2[cH:39][cH:40][cH:41][cH:42][cH:43]2)=[O:37])[n:32][o:33]1)([F:44])[F:45].[F:46][C:47]([F:48])([F:49])[C:50]([c:51]1[o:52][n:53][c:54]([NH:55][C:56](=[O:57])[O-:58])[cH:59]1)([CH3:60])[CH3:61]>>[CH3:1][O:2][c:3]1[cH:4][c:5]2[c:6]([O:15][c:16]3[c:17]([F:23])[c:18]([NH:19][C:35]([NH:34][c:31]4[cH:30][c:29]([C:26]([C:25]([F:24])([F:44])[F:45])([CH3:27])[CH3:28])[o:33][n:32]4)=[O:36])[cH:20][cH:21][cH:22]3)[n:7][cH:8][n:9][c:10]2[cH:11][c:12]1[O:13][CH3:14]Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-72ac8ec124204d1b845a9fda60dbc684
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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