Tetrahydrofuran → 3-(4-Cyclopropyl-2-fluoro-phenylamino)1-methyl-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid (2-vinyloxy-ethoxy)-amide

HRID 1229795Notes

Reaction equation

HRID 1229795 reaction equation
[CH2:65]1[O:66][CH2:67][CH2:68][CH2:69]1.[CH:1]1([c:4]2[cH:5][c:6]([F:24])[c:7]([NH:10][c:11]3[c:12]([C:21](=[O:22])[OH:23])[n:13]([CH3:20])[c:14]4[c:15]3[cH:16][n:17][cH:18][cH:19]4)[cH:8][cH:9]2)[CH2:2][CH2:3]1.[CH:25](=[CH2:26])[O:27][CH2:28][CH2:29][O:30][NH2:31].[CH:56]([N:57]([CH2:58][CH3:59])[CH:60]([CH3:61])[CH3:62])([CH3:63])[CH3:64].[P-:32]([F:33])([F:34])([F:35])([F:36])([F:37])[F:38].[n:39]1([O:40][C:41]([N:42]([CH3:43])[CH3:44])=[N+:45]([CH3:46])[CH3:47])[c:48]2[n:49][cH:50][cH:51][cH:52][c:53]2[n:54][n:55]1>>[CH:1]1([c:4]2[cH:5][c:6]([F:24])[c:7]([NH:10][c:11]3[c:12]([C:21](=[O:23])[NH:31][O:30][CH2:29][CH2:28][O:27][CH:25]=[CH2:26])[n:13]([CH3:20])[c:14]4[c:15]3[cH:16][n:17][cH:18][cH:19]4)[cH:8][cH:9]2)[CH2:2][CH2:3]1

Participants

7

Reactant 6

HCID 8028TetrahydrofuranHCID 9886HexafluorophosphateHCID 81531DiisopropylethylamineHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 21867017O-(2-(Vinyloxy)ethyl)hydroxylamineHCID 595964403-(4-Cyclopropyl-2-fluoro-phenylamino)-1-methyl-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid

Product 1

HCID 595965283-(4-Cyclopropyl-2-fluoro-phenylamino)1-methyl-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid (2-vinyloxy-ethoxy)-amide

Sources & evidence

ORD record
ord-186b03ba1ae749129ba1ad717abfd1cd
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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