Tetrahydrofuran → 4,6-Dibromo-2-(2-chloro-4-fluorophenyl)-3-methylpyridine

HRID 1230124Notes

Reaction equation

HRID 1230124 reaction equation
[Br:1][c:2]1[n:3][c:4](-[c:11]2[c:12]([Cl:18])[cH:13][c:14]([F:17])[cH:15][cH:16]2)[c:5]([CH3:10])[c:6]([Br:9])[c:7]1[NH2:8].[C:19]([O:20][N:21]=[O:22])([CH3:23])([CH3:24])[CH3:25].[CH2:26]1[O:27][CH2:28][CH2:29][CH2:30]1>>[Br:1][c:2]1[n:3][c:4](-[c:11]2[c:12]([Cl:18])[cH:13][c:14]([F:17])[cH:15][cH:16]2)[c:5]([CH3:10])[c:6]([Br:9])[cH:7]1

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 10906Tert-Butyl nitriteHCID 226481982,4-Dibromo-6-(2-chloro-4-fluorophenyl)-5-methylpyridin-3-amine

Product 1

HCID 226480084,6-Dibromo-2-(2-chloro-4-fluorophenyl)-3-methylpyridine

Sources & evidence

ORD record
ord-f552fb21633a4bc49b5c23d2c71edb0d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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