Dichloromethane → 3-[[2,6-Dichloro-4-[4-(morpholine-4-carbonyl)phenyl]phenyl]methyl]-1-[4-tri(propan-2-yl)silyloxypiperidin-1-yl]pyrrolidin-2-one
Reaction equation
[C:42]([n:43]1[cH:44][cH:45][n:46][cH:47]1)([n:48]1[cH:49][cH:50][n:51][cH:52]1)=[O:53].[CH2:54]1[CH2:55][O:56][CH2:57][CH2:58][NH:59]1.[CH3:60][CH2:61][O:62][C:63](=[O:64])[CH3:65].[Cl:1][c:2]1[cH:3][c:4](-[c:33]2[cH:34][cH:35][c:36]([C:39](=[O:40])[OH:41])[cH:37][cH:38]2)[cH:5][c:6]([Cl:32])[c:7]1[CH2:8][CH:9]1[C:10](=[O:31])[N:11]([N:14]2[CH2:15][CH2:16][CH:17]([O:20][Si:21]([CH:22]([CH3:23])[CH3:24])([CH:25]([CH3:26])[CH3:27])[CH:28]([CH3:29])[CH3:30])[CH2:18][CH2:19]2)[CH2:12][CH2:13]1.[Cl:66][CH2:67][Cl:68]>>[Cl:1][c:2]1[cH:3][c:4](-[c:33]2[cH:34][cH:35][c:36]([C:39](=[O:41])[N:59]3[CH2:54][CH2:55][O:56][CH2:57][CH2:58]3)[cH:37][cH:38]2)[cH:5][c:6]([Cl:32])[c:7]1[CH2:8][CH:9]1[C:10](=[O:31])[N:11]([N:14]2[CH2:15][CH2:16][CH:17]([O:20][Si:21]([CH:22]([CH3:23])[CH3:24])([CH:25]([CH3:26])[CH3:27])[CH:28]([CH3:29])[CH3:30])[CH2:18][CH2:19]2)[CH2:12][CH2:13]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-bac882db0ccc42c8a2b70ef777106d69
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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