Dichloromethane → N-Methyl-N-[1-(tetrahydro-2H-pyran-4-ylmethyl)-2-(trifluoromethyl)-1H-benzimidazol-5-yl]propane-1-sulfonamide

HRID 1231196Notes

Reaction equation

HRID 1231196 reaction equation
[CH2:1]([CH2:2][CH3:3])[S:4](=[O:5])(=[O:6])[Cl:7].[CH3:39][N:40]([c:41]1[cH:42][cH:43][n:44][cH:45][cH:46]1)[CH3:47].[CH3:8][NH:9][c:10]1[cH:11][c:12]2[c:13]([n:14]([CH2:21][CH:22]3[CH2:23][CH2:24][O:25][CH2:26][CH2:27]3)[c:15]([C:17]([F:18])([F:19])[F:20])[n:16]2)[cH:28][cH:29]1.[CH:30]([N:31]([CH2:32][CH3:33])[CH:34]([CH3:35])[CH3:36])([CH3:37])[CH3:38].[Cl:48][CH2:49][Cl:50]>>[CH2:1]([CH2:2][CH3:3])[S:4](=[O:5])(=[O:6])[N:9]([CH3:8])[c:10]1[cH:11][c:12]2[c:13]([n:14]([CH2:21][CH:22]3[CH2:23][CH2:24][O:25][CH2:26][CH2:27]3)[c:15]([C:17]([F:18])([F:19])[F:20])[n:16]2)[cH:28][cH:29]1

Participants

6

Reactant 5

HCID 6344DichloromethaneHCID 142844-(Dimethylamino)pyridineHCID 662791-Propanesulfonyl chlorideHCID 81531DiisopropylethylamineHCID 57441079HCID 57441079, compound

Product 1

HCID 57441070N-Methyl-N-[1-(tetrahydro-2H-pyran-4-ylmethyl)-2-(trifluoromethyl)-1H-benzimidazol-5-yl]propane-1-sulfonamide

Sources & evidence

ORD record
ord-92c4ec9235fa4a6597205a9abfba0fd8
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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