Methanol → 1-(4-Chlorophenyl)-1,3,8-triazaspiro[4.5]decan-4-one
Reaction equation
[CH2:37]1[O:38][CH2:39][CH2:40][CH2:41]1.[CH3:43][OH:44].[F:1][C:2]([F:3])([F:4])[c:5]1[cH:6][c:7]([C:33]([N:8]2[CH2:9][CH2:10][C:11]3([C:12](=[O:23])[NH:13][CH2:14][N:15]3[c:16]3[cH:17][cH:18][c:19]([Cl:22])[cH:20][cH:21]3)[CH2:24][CH2:25]2)=[O:34])[cH:26][c:27]([C:28]([F:29])([F:30])[F:31])[cH:32]1.[Li+:36].[OH-:35].[OH2:42]>>[NH:8]1[CH2:9][CH2:10][C:11]2([C:12](=[O:23])[NH:13][CH2:14][N:15]2[c:16]2[cH:17][cH:18][c:19]([Cl:22])[cH:20][cH:21]2)[CH2:24][CH2:25]1Participants
7
Sources & evidence
- ORD record
- ord-fc788127397f4a99ab810736445c6b10
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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