Bicarbonate Ion → 2-(5-chloro-2-fluoro-phenyl)-4-[5-(1-methyl-1H-pyrazol-4-yl)-pyridin-3-yl]-[1,8]naphthyridine
Reaction equation
[C:41](=[O:42])([OH:43])[O-:44].[CH3:20][n:21]1[n:22][cH:23][c:24](-[c:26]2[cH:27][n:28][cH:29][c:30]([B:32]3[O:33][C:34]([CH3:35])([CH3:36])[C:37]([CH3:38])([CH3:39])[O:40]3)[cH:31]2)[cH:25]1.[Cl:1][c:2]1[cH:3][c:4](-[c:12]2[c:13]([F:19])[cH:14][cH:15][c:16]([Cl:18])[cH:17]2)[n:5][c:6]2[n:7][cH:8][cH:9][cH:10][c:11]12.[Na+:45].[O:46]=[CH:47][N:48]([CH3:49])[CH3:50].[OH2:51].[Pd:52]([Cl:53])[Cl:54].[c:55]1([P:56]([c:57]2[cH:58][cH:59][cH:60][cH:61][cH:62]2)[c:63]2[cH:64][cH:65][cH:66][cH:67][cH:68]2)[cH:69][cH:70][cH:71][cH:72][cH:73]1.[c:74]1([P:75]([c:76]2[cH:77][cH:78][cH:79][cH:80][cH:81]2)[c:82]2[cH:83][cH:84][cH:85][cH:86][cH:87]2)[cH:88][cH:89][cH:90][cH:91][cH:92]1>>[c:2]1(-[c:30]2[cH:29][n:28][cH:27][c:26](-[c:24]3[cH:23][n:22][n:21]([CH3:20])[cH:25]3)[cH:31]2)[cH:3][c:4](-[c:12]2[c:13]([F:19])[cH:14][cH:15][c:16]([Cl:18])[cH:17]2)[n:5][c:6]2[n:7][cH:8][cH:9][cH:10][c:11]12Participants
9
Reactant 8
Product 1
Sources & evidence
- ORD record
- ord-89bee2aa4ca04b6992287d64c8560664
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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