Diethyl Ether → Hydrochloric Acid

HRID 1232058Notes

Reaction equation

HRID 1232058 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[cH:10][cH:11][c:12]2[c:13]([Cl:19])[n:14][cH:15][n:16][c:17]2[cH:18]1.[CH3:37][C:38]([N:39]([CH3:40])[CH3:41])=[O:42].[CH3:43][CH2:44][O:45][CH2:46][CH3:47].[NH2:20][c:21]1[cH:22][n:23][n:24]([CH2:26][C:27](=[O:28])[NH:29][c:30]2[cH:31][c:32]([F:36])[cH:33][cH:34][cH:35]2)[cH:25]1>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[cH:10][cH:11][c:12]2[c:13]([NH:20][c:21]3[cH:22][n:23][n:24]([CH2:26][C:27](=[O:28])[NH:29][c:30]4[cH:31][c:32]([F:36])[cH:33][cH:34][cH:35]4)[cH:25]3)[n:14][cH:15][n:16][c:17]2[cH:18]1.[ClH:19]

Participants

6

Reactant 4

HCID 3283Diethyl EtherHCID 31374DimethylacetamideHCID 220309237-(Benzyloxy)-4-chloroquinazolineHCID 283740072-(4-amino-1H-pyrazol-1-yl)-N-(3-fluorophenyl)acetamide

Product 2

HCID 313Hydrochloric AcidHCID 68638366N-(3-fluorophenyl)-2-[4-[(7-phenylmethoxyquinazolin-4-yl)amino]pyrazol-1-yl]acetamide

Sources & evidence

ORD record
ord-4f4e35bdbbe6418bbd32d18c43396e03
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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