Dimethylformamide → 4-chloro-8-(2,4-difluorophenyl)-2-{[2-hydroxy-1-(hydroxymethyl)ethyl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one
Reaction equation
[Cl:1][c:2]1[c:3]2[c:4]([n:5][c:6]([S:8]([CH3:9])=[O:10])[n:7]1)[n:11](-[c:16]1[c:17]([F:23])[cH:18][c:19]([F:22])[cH:20][cH:21]1)[c:12](=[O:15])[cH:13][cH:14]2.[Cl:30][CH2:31][Cl:32].[NH2:24][CH:25]([CH2:26][OH:27])[CH2:28][OH:29].[O:33]=[CH:34][N:35]([CH3:36])[CH3:37]>>[Cl:1][c:2]1[c:3]2[c:4]([n:5][c:6]([NH:24][CH:25]([CH2:26][OH:27])[CH2:28][OH:29])[n:7]1)[n:11](-[c:16]1[c:17]([F:23])[cH:18][c:19]([F:22])[cH:20][cH:21]1)[c:12](=[O:15])[cH:13][cH:14]2Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-54b5474896e648a6be53d8f37fcbc9ae
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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