Hydrochloric Acid → N-(2-Chloro-4-{[6-methoxy-7-(2-morpholinoethoxy)-4-quinolyl]oxy}phenyl)-N'-(2,4-difluorophenyl)urea

HRID 1232918Notes

Reaction equation

HRID 1232918 reaction equation
[C:34](=[O:35])([O-:36])[O-:37].[CH2:61]([N+:62]([CH2:63][CH2:64][CH2:65][CH3:66])([CH2:67][CH2:68][CH2:69][CH3:70])[CH2:71][CH2:72][CH2:73][CH3:74])[CH2:75][CH2:76][CH3:77].[CH3:55][N:56]([CH3:57])[CH:58]=[O:59].[Cl:1][c:2]1[c:3]([NH:22][C:23](=[O:24])[NH:25][c:26]2[c:27]([F:33])[cH:28][c:29]([F:32])[cH:30][cH:31]2)[cH:4][cH:5][c:6]([O:8][c:9]2[cH:10][cH:11][n:12][c:13]3[cH:14][c:15]([OH:21])[c:16]([O:19][CH3:20])[cH:17][c:18]23)[cH:7]1.[Cl:41][CH2:42][CH2:43][N:44]1[CH2:45][CH2:46][O:47][CH2:48][CH2:49]1.[ClH:40].[I-:60].[K+:38].[K+:39].[Na+:50].[OH:51][C:52](=[O:53])[O-:54]>>[Cl:1][c:2]1[c:3]([NH:22][C:23](=[O:24])[NH:25][c:26]2[c:27]([F:33])[cH:28][c:29]([F:32])[cH:30][cH:31]2)[cH:4][cH:5][c:6]([O:8][c:9]2[cH:10][cH:11][n:12][c:13]3[cH:14][c:15]([O:21][CH2:42][CH2:43][N:44]4[CH2:45][CH2:46][O:47][CH2:48][CH2:49]4)[c:16]([O:19][CH3:20])[cH:17][c:18]23)[cH:7]1

Participants

11

Reactant 10

HCID 313Hydrochloric AcidHCID 769Bicarbonate IonHCID 813Potassium Cation2×HCID 923Sodium ionHCID 6228DimethylformamideHCID 16028TetrabutylammoniumHCID 19660Carbonate IonHCID 30165Iodide IonHCID 767274-(2-Chloroethyl)morpholineHCID 135674212N-{2-Chloro-4-[(7-hydroxy-6-methoxy-4-quinolyl)-oxy]phenyl}-N'-(2,4-difluorophenyl)urea

Product 1

HCID 9808488N-(2-Chloro-4-{[6-methoxy-7-(2-morpholinoethoxy)-4-quinolyl]oxy}phenyl)-N'-(2,4-difluorophenyl)urea

Sources & evidence

ORD record
ord-07d0c1bf50f549ee935769622d5f3833
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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