Ethyl Acetate → Ethyl 2-(2,7-dichloro-6-fluoroquinoline-3-carbonyl)-3-dimethylaminoacrylate

HRID 1233567Notes

Reaction equation

HRID 1233567 reaction equation
[CH3:22][O:23][CH:24]([N:25]([CH3:26])[CH3:27])[O:28][CH3:29].[CH3:30][CH2:31][O:32][C:33](=[O:34])[CH3:35].[Cl:1][c:2]1[n:3][c:4]2[cH:5][c:6]([Cl:21])[c:7]([F:20])[cH:8][c:9]2[cH:10][c:11]1[C:12]([CH2:13][C:14](=[O:15])[O:16][CH2:17][CH3:18])=[O:19]>>[Cl:1][c:2]1[n:3][c:4]2[cH:5][c:6]([Cl:21])[c:7]([F:20])[cH:8][c:9]2[cH:10][c:11]1[C:12]([C:13]([C:14](=[O:15])[O:16][CH2:17][CH3:18])=[CH:24][N:25]([CH3:26])[CH3:27])=[O:19]

Participants

4

Reactant 3

HCID 8857Ethyl AcetateHCID 78373Dimethylformamide dimethyl acetalHCID 14726625Ethyl 3-(2,7-dichloro-6-fluoro-3-quinolyl)-3-oxopropionate

Product 1

HCID 54015905Ethyl 2-(2,7-dichloro-6-fluoroquinoline-3-carbonyl)-3-dimethylaminoacrylate

Sources & evidence

ORD record
ord-36d2ecba1e534bee9839dc1340b3557c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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