Piperazine → PRX-07034 free base

HRID 1234314Notes

Reaction equation

HRID 1234314 reaction equation
[CH2:26]1[CH2:27][NH:28][CH2:29][CH2:30][NH:31]1.[CH3:41][C:42]#[N:43].[CH:32]([N:33]([CH2:34][CH3:35])[CH:36]([CH3:37])[CH3:38])([CH3:39])[CH3:40].[Cl:1][c:2]1[cH:3][c:4]([O:24][CH3:25])[c:5]([O:22][CH3:23])[c:6]([CH:8]([CH3:9])[NH:10][c:11]2[c:12]([S:18](=[O:19])(=[O:20])[CH3:21])[cH:13][cH:14][c:15]([F:17])[cH:16]2)[cH:7]1>>[Cl:1][c:2]1[cH:3][c:4]([O:24][CH3:25])[c:5]([O:22][CH3:23])[c:6]([CH:8]([CH3:9])[NH:10][c:11]2[c:12]([S:18](=[O:19])(=[O:20])[CH3:21])[cH:13][cH:14][c:15]([N:28]3[CH2:27][CH2:26][NH:31][CH2:30][CH2:29]3)[cH:16]2)[cH:7]1

Participants

5

Reactant 4

HCID 4837PiperazineHCID 6342AcetonitrileHCID 81531DiisopropylethylamineHCID 44240863N-(1-(5-Chloro-2,3-dimethoxyphenyl)ethyl)-5-fluoro-2-(methylsulfonyl)benzenamine

Product 1

HCID 11532574PRX-07034 free base

Sources & evidence

ORD record
ord-35566e74d9b444418994c14378ee0f7d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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