Acetate → 5-(2-Pyridin-4-ylfuran-3-yl)indan-1-one

HRID 1235049Notes

Reaction equation

HRID 1235049 reaction equation
[Br:1][c:2]1[c:3](-[c:7]2[cH:8][cH:9][n:10][cH:11][cH:12]2)[o:4][cH:5][cH:6]1.[CH3:13][C:14]1([CH3:15])[C:16]([CH3:17])([CH3:18])[O:19][B:20]([c:21]2[cH:22][c:23]3[c:27]([cH:28][cH:29]2)[C:26](=[O:30])[CH2:25][CH2:24]3)[O:31]1.[CH3:33][C:34](=[O:35])[O-:36].[CH3:56][N:57]([CH3:58])[CH:59]=[O:60].[CH3:61][CH2:62][OH:63].[K+:32].[O-:66][C:67]([CH3:68])=[O:69].[O-:70][C:71]([CH3:72])=[O:73].[OH2:64].[Pd+2:65].[c:37]1([P:38]([c:39]2[cH:40][cH:41][cH:42][cH:43][cH:44]2)[c:45]2[cH:46][cH:47][cH:48][cH:49][cH:50]2)[cH:51][cH:52][cH:53][cH:54][cH:55]1>>[c:2]1(-[c:21]2[cH:22][c:23]3[c:27]([cH:28][cH:29]2)[C:26](=[O:30])[CH2:25][CH2:24]3)[c:3](-[c:7]2[cH:8][cH:9][n:10][cH:11][cH:12]2)[o:4][cH:5][cH:6]1

Participants

10

Reactant 9

HCID 175Acetate3×HCID 702EthanolHCID 813Potassium CationHCID 962WaterHCID 6228DimethylformamideHCID 11776TriphenylphosphineHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 157218314-(3-Bromo-furan-2-yl)-pyridineHCID 185417105-(tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-inden-1-one

Product 1

HCID 694314975-(2-Pyridin-4-ylfuran-3-yl)indan-1-one

Sources & evidence

ORD record
ord-2c7bf2ada522462fb0ad83cf5c2839b4
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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