Dimethylformamide → 5-(2-(2-(1,3-dioxoisoindolin-2-yl)ethoxy)-5-(isobutylcarbamoyl)phenyl)-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide

HRID 1235653Notes

Reaction equation

HRID 1235653 reaction equation
[Br:35][CH2:36][CH2:37][N:38]1[C:39](=[O:48])[c:40]2[cH:41][cH:42][cH:43][cH:44][c:45]2[C:46]1=[O:47].[CH2:49]1[CH2:50][CH2:51][C:52]2=[N:57][CH2:56][CH2:55][CH2:54][N:53]2[CH2:58][CH2:59]1.[F:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[o:9][c:10]3[c:11]([c:12]2[C:13](=[O:14])[NH:15][CH3:16])[cH:17][c:18](-[c:21]2[c:22]([OH:34])[cH:23][cH:24][c:25]([C:27]([NH:28][CH2:29][CH:30]([CH3:31])[CH3:32])=[O:33])[cH:26]2)[cH:19][cH:20]3)[cH:6][cH:7]1.[O:60]=[CH:61][N:62]([CH3:63])[CH3:64]>>[F:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[o:9][c:10]3[c:11]([c:12]2[C:13](=[O:14])[NH:15][CH3:16])[cH:17][c:18](-[c:21]2[c:22]([O:34][CH2:36][CH2:37][N:38]4[C:39](=[O:48])[c:40]5[cH:41][cH:42][cH:43][cH:44][c:45]5[C:46]4=[O:47])[cH:23][cH:24][c:25]([C:27]([NH:28][CH2:29][CH:30]([CH3:31])[CH3:32])=[O:33])[cH:26]2)[cH:19][cH:20]3)[cH:6][cH:7]1

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 113251H-Isoindole-1,3(2H)-dione, 2-(2-bromoethyl)-HCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 592753492-(4-fluorophenyl)-5-(2-hydroxy-5-(isobutylcarbamoyl)phenyl)-N-methylbenzofuran-3-carboxamide

Product 1

HCID 592751985-(2-(2-(1,3-dioxoisoindolin-2-yl)ethoxy)-5-(isobutylcarbamoyl)phenyl)-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide

Sources & evidence

ORD record
ord-cd9cd9f3c980466caacba633dfe316f2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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