Water → Tert-butyl 4-{2-[(3,5-bis-trifluoromethyl-benzyl)-(4'-fluoro-5'-isopropyl-4,5,2'-trimethoxy-biphenyl-2-ylmethyl)-amino]-pyrimidin-5-yloxy}-butyrate
Reaction equation
[C:61](=[O:62])([O-:63])[O-:64].[CH2:73]1[O:74][CH2:75][CH2:76][O:77][CH2:78]1.[CH3:67][CH2:68][O:69][C:70](=[O:71])[CH3:72].[Cs+:65].[Cs+:66].[F:1][C:2]([c:3]1[cH:4][c:5]([CH2:6][N:7]([c:8]2[n:9][cH:10][c:11]([O:14][CH2:15][CH2:16][CH2:17][C:18](=[O:19])[O:20][C:21]([CH3:22])([CH3:23])[CH3:24])[cH:12][n:13]2)[CH2:25][c:26]2[c:27]([Br:36])[cH:28][c:29]([O:34][CH3:35])[c:30]([O:32][CH3:33])[cH:31]2)[cH:37][c:38]([C:40]([F:41])([F:42])[F:43])[cH:39]1)([F:44])[F:45].[F:46][c:47]1[cH:48][c:49]([O:59][CH3:60])[c:50]([B:56]([OH:57])[OH:58])[cH:51][c:52]1[CH:53]([CH3:54])[CH3:55].[OH2:79]>>[F:1][C:2]([c:3]1[cH:4][c:5]([CH2:6][N:7]([c:8]2[n:9][cH:10][c:11]([O:14][CH2:15][CH2:16][CH2:17][C:18](=[O:19])[O:20][C:21]([CH3:22])([CH3:23])[CH3:24])[cH:12][n:13]2)[CH2:25][c:26]2[c:27](-[c:50]3[c:49]([O:59][CH3:60])[cH:48][c:47]([F:46])[c:52]([CH:53]([CH3:54])[CH3:55])[cH:51]3)[cH:28][c:29]([O:34][CH3:35])[c:30]([O:32][CH3:33])[cH:31]2)[cH:37][c:38]([C:40]([F:41])([F:42])[F:43])[cH:39]1)([F:44])[F:45]Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-858313dab51749d9818c7a3f5cd3f43b
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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