Tetrahydrofuran → 2-[5-(4-bromo-3-hydroxymethyl-phenyl)-1H-imidazol-2-yl]-pyrrolidine-1-carboxylic acid tert-butyl ester
Reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH:9]([c:13]2[nH:14][c:15](-[c:18]3[cH:19][c:20]([C:25](=[O:26])[O:27][CH3:28])[c:21]([Br:24])[cH:22][cH:23]3)[cH:16][n:17]2)[CH2:10][CH2:11][CH2:12]1.[CH2:38]1[O:39][CH2:40][CH2:41][CH2:42]1.[CH2:43]1[O:44][CH2:45][CH2:46][CH2:47]1.[CH3:29][CH:30]([CH2:31][AlH:32][CH2:33][CH:34]([CH3:35])[CH3:36])[CH3:37]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH:9]([c:13]2[nH:14][c:15](-[c:18]3[cH:19][c:20]([CH2:25][OH:26])[c:21]([Br:24])[cH:22][cH:23]3)[cH:16][n:17]2)[CH2:10][CH2:11][CH2:12]1Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-1e53b7142fa64833bd259a253da0d680
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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