Dimethyl Sulfoxide → Tert-butyl 4-(4-fluorophenyl)-3-formylpiperidine-1-carboxylate

HRID 123734Notes

Reaction equation

HRID 123734 reaction equation
[CH2:40]([Cl:41])[Cl:42].[CH3:1][S:2](=[O:3])[CH3:4].[CH3:33][CH2:34][N:35]([CH2:36][CH3:37])[CH2:38][CH3:39].[Cl:5][C:6]([C:7]([Cl:8])=[O:9])=[O:10].[F:11][c:12]1[cH:13][cH:14][c:15]([CH:18]2[CH:19]([CH2:31][OH:32])[CH2:20][N:21]([C:24](=[O:25])[O:26][C:27]([CH3:28])([CH3:29])[CH3:30])[CH2:22][CH2:23]2)[cH:16][cH:17]1>>[F:11][c:12]1[cH:13][cH:14][c:15]([CH:18]2[CH:19]([CH:31]=[O:32])[CH2:20][N:21]([C:24](=[O:25])[O:26][C:27]([CH3:28])([CH3:29])[CH3:30])[CH2:22][CH2:23]2)[cH:16][cH:17]1

Participants

6

Reactant 5

HCID 679Dimethyl SulfoxideHCID 6344DichloromethaneHCID 8471TriethylamineHCID 65578Oxalyl chlorideHCID 226439871,1-Dimethylethyl 4-(4-fluorophenyl)-3-(hydroxymethyl)-1-piperidinecarboxylate

Product 1

HCID 86604441Tert-butyl 4-(4-fluorophenyl)-3-formylpiperidine-1-carboxylate

Sources & evidence

ORD record
ord-45a6d37cb7ad4cfba2db232e1e11432f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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