Tetrahydrofuran → 1-(6-Bromopyridin-3-yl)-1-[5-(3-methyl-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]ethanol
Reaction equation
[Br:32][c:33]1[cH:34][cH:35][c:36]([C:39]([CH3:40])=[O:41])[cH:37][n:38]1.[CH2:42]1[O:43][CH2:44][CH2:45][CH2:46]1.[CH3:9][c:10]1[cH:11][c:12]([NH:21][c:22]2[n:23][cH:24][cH:25][c:26]([C:28]([F:29])([F:30])[F:31])[n:27]2)[cH:13][c:14](-[c:16]2[cH:17][n:18][cH:19][s:20]2)[cH:15]1.[CH:1]([N-:2][CH:3]([CH3:4])[CH3:5])([CH3:6])[CH3:7].[Li+:8]>>[CH3:9][c:10]1[cH:11][c:12]([NH:21][c:22]2[n:23][cH:24][cH:25][c:26]([C:28]([F:29])([F:30])[F:31])[n:27]2)[cH:13][c:14](-[c:16]2[cH:17][n:18][c:19]([C:39]([c:36]3[cH:35][cH:34][c:33]([Br:32])[n:38][cH:37]3)([CH3:40])[OH:41])[s:20]2)[cH:15]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-171e9613a1234f05a3eab1718f3ec993
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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