1,2-Dichloroethane → N-[1-cyclopropylmethyl-4-(4-iodo-phenyl)-piperidin-4-ylmethyl]-2-(3,5-difluoro-phenyl)-acetamide

HRID 1238352Notes

Reaction equation

HRID 1238352 reaction equation
[C:32]([OH:33])(=[O:34])[CH3:35].[CH2:36]([Cl:37])[CH2:38][Cl:39].[CH3:40][CH2:41][O:42][C:43]([CH3:44])=[O:45].[CH:27]1([CH:30]=[O:31])[CH2:28][CH2:29]1.[F:1][c:2]1[cH:3][c:4]([CH2:9][C:10](=[O:11])[NH:12][CH2:13][C:14]2([c:20]3[cH:21][cH:22][c:23]([I:26])[cH:24][cH:25]3)[CH2:15][CH2:16][NH:17][CH2:18][CH2:19]2)[cH:5][c:6]([F:8])[cH:7]1>>[F:1][c:2]1[cH:3][c:4]([CH2:9][C:10](=[O:11])[NH:12][CH2:13][C:14]2([c:20]3[cH:21][cH:22][c:23]([I:26])[cH:24][cH:25]3)[CH2:15][CH2:16][N:17]([CH2:30][CH:27]3[CH2:28][CH2:29]3)[CH2:18][CH2:19]2)[cH:5][c:6]([F:8])[cH:7]1

Participants

6

Reactant 5

HCID 111,2-DichloroethaneHCID 176Acetic AcidHCID 8857Ethyl AcetateHCID 123114CyclopropanecarboxaldehydeHCID 224903764-{[2-(3,5-Difluoro-phenyl)-acetylamino]-methyl}-4-(4-iodo-phenyl)-piperidine

Product 1

HCID 68533825N-[1-cyclopropylmethyl-4-(4-iodo-phenyl)-piperidin-4-ylmethyl]-2-(3,5-difluoro-phenyl)-acetamide

Sources & evidence

ORD record
ord-b5b718652c0240768893fb64e35b1310
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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