Potassium Cation → 3-[5-(2-Fluoro-phenyl]-pyridin-2-yloxy]-azetidine-1-carboxylic acid pyrazin-2-ylamide

HRID 1238394Notes

Reaction equation

HRID 1238394 reaction equation
[C:32](=[O:33])([O-:34])[O-:35].[CH2:52]1[O:53][CH2:54][CH2:55][CH2:56]1.[CH3:41][CH2:42][O:43][C:44](=[O:45])[CH3:46].[CH3:47][CH2:48][O:49][CH2:50][CH3:51].[Cl:38][CH2:39][Cl:40].[F:22][c:23]1[c:24]([B:29]([OH:30])[OH:31])[cH:25][cH:26][cH:27][cH:28]1.[K+:36].[K+:37].[OH2:57].[n:1]1[c:2]([NH:7][C:8](=[O:9])[N:10]2[CH2:11][CH:12]([O:14][c:15]3[n:16][cH:17][c:18]([Br:21])[cH:19][cH:20]3)[CH2:13]2)[cH:3][n:4][cH:5][cH:6]1>>[n:1]1[c:2]([NH:7][C:8](=[O:9])[N:10]2[CH2:11][CH:12]([O:14][c:15]3[n:16][cH:17][c:18](-[c:24]4[c:23]([F:22])[cH:28][cH:27][cH:26][cH:25]4)[cH:19][cH:20]3)[CH2:13]2)[cH:3][n:4][cH:5][cH:6]1

Participants

10

Reactant 9

HCID 813Potassium Cation2×HCID 962WaterHCID 3283Diethyl EtherHCID 6344DichloromethaneHCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 19660Carbonate IonHCID 27343542-Fluorophenylboronic acidHCID 66710701HCID 66710701, compound

Product 1

HCID 442192113-[5-(2-Fluoro-phenyl]-pyridin-2-yloxy]-azetidine-1-carboxylic acid pyrazin-2-ylamide

Sources & evidence

ORD record
ord-70fd286009564ee48e989b110f97d47c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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