Phosphorus oxychloride → Ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate
Reaction equation
[F:1][c:2]1[c:3](-[n:9]2[cH:10][c:11]([C:23](=[O:24])[O:25][CH2:26][CH3:27])[c:12](=[O:22])[c:13]3[cH:14][c:15]([F:21])[c:16]([O:19][CH3:20])[n:17][c:18]23)[cH:4][cH:5][c:6]([F:8])[cH:7]1.[P:28]([Cl:29])([Cl:30])([Cl:31])=[O:32]>>[F:1][c:2]1[c:3](-[n:9]2[cH:10][c:11]([C:23](=[O:24])[O:25][CH2:26][CH3:27])[c:12](=[O:22])[c:13]3[cH:14][c:15]([F:21])[c:16]([Cl:30])[n:17][c:18]23)[cH:4][cH:5][c:6]([F:8])[cH:7]1Participants
3
Sources & evidence
- ORD record
- ord-2ca8dddc0a2c48aa910a48e477e60eb5
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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