Bromide ion → tert-butyl N-[3-(2,2,3,3-tetramethylcyclopropanecarbonyl)-1H-indol-5-yl]carbamate

HRID 1240112Notes

Reaction equation

HRID 1240112 reaction equation
[Br-:18].[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([NH:7][c:8]1[cH:9][c:10]2[cH:11][cH:12][nH:13][c:14]2[cH:15][cH:16]1)=[O:17].[CH2:19]([Mg+:20])[CH3:21].[CH3:22][C:23]1([CH3:31])[CH:24]([C:28](=[O:29])[Cl:30])[C:25]1([CH3:26])[CH3:27].[Cl-:35].[Cl-:37].[Cl:32][CH2:33][Cl:34].[Zn+2:36]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([NH:7][c:8]1[cH:9][c:10]2[c:11]([C:28]([CH:24]3[C:23]([CH3:22])([CH3:31])[C:25]3([CH3:26])[CH3:27])=[O:29])[cH:12][nH:13][c:14]2[cH:15][cH:16]1)=[O:17]

Participants

8

Reactant 7

HCID 259Bromide ionHCID 312Chloride2×HCID 6344DichloromethaneHCID 32051Zinc(2+)HCID 110410022,2,3,3-Tetramethylcyclopropane-1-carbonyl chlorideHCID 114589235-N-Boc-amino-1H-indoleHCID 178461628HCID 178461628, compound

Product 1

HCID 67269870tert-butyl N-[3-(2,2,3,3-tetramethylcyclopropanecarbonyl)-1H-indol-5-yl]carbamate

Sources & evidence

ORD record
ord-72a8d3f3608a452183d9275c09d0cbde
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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