Water → Tert-butyl 3-(aminocarbonyl)-3-[({4-[(3-chloro-2-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}methyl)(methyl)amino]azetidine-1-carboxylate
Reaction equation
[CH3:50][N:51]([CH3:52])[CH:53]=[O:54].[CH:1]([N:2]([CH2:3][CH3:4])[CH:5]([CH3:6])[CH3:7])([CH3:8])[CH3:9].[Cl:10][c:11]1[c:12]([F:32])[c:13]([NH:17][c:18]2[n:19][cH:20][n:21][c:22]3[cH:23][c:24]([O:30][CH3:31])[c:25]([CH2:28][Cl:29])[cH:26][c:27]23)[cH:14][cH:15][cH:16]1.[NH2:33][C:34](=[O:35])[C:36]1([NH:47][CH3:48])[CH2:37][N:38]([C:40](=[O:41])[O:42][C:43]([CH3:44])([CH3:45])[CH3:46])[CH2:39]1.[OH2:49]>>[Cl:10][c:11]1[c:12]([F:32])[c:13]([NH:17][c:18]2[n:19][cH:20][n:21][c:22]3[cH:23][c:24]([O:30][CH3:31])[c:25]([CH2:28][N:47]([C:36]4([C:34]([NH2:33])=[O:35])[CH2:37][N:38]([C:40](=[O:41])[O:42][C:43]([CH3:44])([CH3:45])[CH3:46])[CH2:39]4)[CH3:48])[cH:26][c:27]23)[cH:14][cH:15][cH:16]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-25ad8beb8e494231a1247d7841659ef8
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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