Methanol → 4-[4-(2-fluoroethyl)-3-(2-methoxyethyl)piperazin-1-yl]-2-(trifluoromethyl)-10H-[1,3]thiazolo[5,4-b][1,5]benzodiazepine
Reaction equation
[BH3:6].[CH3:39][OH:40].[Cl:51][CH2:52][Cl:53].[F:7][CH2:8][C:9](=[O:10])[N:11]1[CH:12]([CH2:35][CH2:36][O:37][CH3:38])[CH2:13][N:14]([C:17]2=[N:18][c:19]3[c:20]([cH:31][cH:32][cH:33][cH:34]3)[NH:21][c:22]3[s:23][c:24]([C:27]([F:28])([F:29])[F:30])[n:25][c:26]32)[CH2:15][CH2:16]1.[NH2:41][CH2:42][CH2:43][NH2:44].[O:1]1[CH2:2][CH2:3][CH2:4][CH2:5]1.[O:45]1[CH2:46][CH2:47][CH2:48][CH2:49]1.[OH2:50]>>[F:7][CH2:8][CH2:9][N:11]1[CH:12]([CH2:35][CH2:36][O:37][CH3:38])[CH2:13][N:14]([C:17]2=[N:18][c:19]3[c:20]([cH:31][cH:32][cH:33][cH:34]3)[NH:21][c:22]3[s:23][c:24]([C:27]([F:28])([F:29])[F:30])[n:25][c:26]32)[CH2:15][CH2:16]1Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-1093b208cdda4e029e61cb97f59c961e
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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