Ammonium Hydroxide → HCID 178473905, compound

HRID 1241523Notes

Reaction equation

HRID 1241523 reaction equation
[N:1]1([CH2:6][C:7]2[CH:12]=[CH:11][C:10]([C@@H:13]3[CH2:16][C@H:15]([CH2:17]OS(C4C=CC(C)=CC=4)(=O)=O)[CH2:14]3)=[CH:9][CH:8]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[NH4+:29].[OH-:30]>CO.C(Cl)Cl>[N:1]1([CH2:6][C:7]2[CH:8]=[CH:9][C:10]([C@@H:13]3[CH2:14][C@H:15]([CH2:17][N:29]4[CH2:4][CH2:5][N:1]([C:6](=[O:30])[CH3:7])[CH2:2][CH2:3]4)[CH2:16]3)=[CH:11][CH:12]=2)[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 178427759HCID 178427759, compound

Product 1

HCID 178473905HCID 178473905, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

Preparation as described for Example 100, General Procedure A, Step H, using the appropriated amine and the tosylate of Example 47 (cis-toluene-4-sulfonic acid 3-(4-pyrrolidin-1-ylmethyl-phenyl)-cyclobutylmethyl ester). Rf=0.24 (20% MeOH/CH2Cl2 w/0.5% NH4OH); LRMS m/z Calcd for C22H33N3O 355.5; obsd LRMS APCI (M+1) m/z 356.

Workup

  1. customPreparation

Sources & evidence

ORD record
ord-ec1b987ccf364584a0d6f4584cfec659
Source dataset
uspto-grants-2006_10
Patent number
US07115600B2

Reaction notes

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