Hydrochloric Acid → HCID 54720303, compound

HRID 1241543Notes

Reaction equation

HRID 1241543 reaction equation
C(OC([C:6]1[C:7](=[O:25])[N:8](CC)[C:9]([CH3:22])=[C:10]([CH2:13][CH2:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:11]=1[OH:12])=O)C.[OH-].[Na+].Cl>O>[OH:12][C:11]1[C:10]([CH2:13][CH2:14][CH2:15][C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)=[C:9]([CH3:22])[NH:8][C:7](=[O:25])[CH:6]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 69640128HCID 69640128, compound

Product 1

HCID 54720303HCID 54720303, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of intermediate 24 (0.1 g; 0.003 mol) and sodium hydroxide (0.038 g; 0.0009 mol) in H2O (1.5 ml) was stirred and refluxed for 15 hours, then cooled to 5° C. with HCl 3N. The precipitate was filtered, washed with H2O, then with isopropanol and dried to yield 0.07 g (91%).

Workup

  1. temperaturerefluxed for 15 hours
  2. filtrationThe precipitate was filtered
  3. washwashed with H2O
  4. dry with materialwith isopropanol and dried
  5. customto yield 0.07 g (91%)

Sources & evidence

ORD record
ord-55452cd664a643c584e78591ec2c94b1
Source dataset
uspto-grants-2006_10
Patent number
US07115608B2

Reaction notes

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