Trifluoromethanesulfonic anhydride → HCID 11145051, compound

HRID 1241701Notes

Reaction equation

HRID 1241701 reaction equation
[F:1][C:2]([F:15])([F:14])[S:3]([O:6]S(C(F)(F)F)(=O)=O)(=[O:5])=[O:4].[Cl:16][C:17]1[CH:18]=[CH:19][C:20]2[C:21]3[N:39]=[C:38]4[C:33]([CH:34]=[CH:35][CH:36]=[CH:37]4)=[C:23]4[CH:24]=[C:25](O)[CH:26]=[C:27]([N:28]([CH3:31])[C:29]=2[CH:30]=1)[C:22]=34>C(Cl)Cl>[Cl:16][C:17]1[CH:18]=[CH:19][C:20]2[C:21]3[N:39]=[C:38]4[C:33]([CH:34]=[CH:35][CH:36]=[CH:37]4)=[C:23]4[CH:24]=[C:25]([O:6][S:3]([C:2]([F:15])([F:14])[F:1])(=[O:5])=[O:4])[CH:26]=[C:27]([N:28]([CH3:31])[C:29]=2[CH:30]=1)[C:22]=34

Participants

4

Reactant 2

HCID 67749Trifluoromethanesulfonic anhydrideHCID 178479883HCID 178479883, compound2×

Product 1

HCID 11145051HCID 11145051, compoundYield 81%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The general procedure (Method L) applied to trifluoromethanesulphonic acid anhydride (0.05 ml, 0.3 mmol, 1 eq), 10-chloro-6-hydroxy-8-methyl-8H-quino[4,3,2-kl]acridine, 37 (100 mg, 0.3 mmol) in DCM (50 mL) gave the title compound as a yellow solid, (114 mg, 0.25 mmol, 81%).

Sources & evidence

ORD record
ord-ec5233da71524c36bd618d73ccec8fbd
Source dataset
uspto-grants-2006_10
Patent number
US07115619B2

Reaction notes

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