Trifluoroacetic acid → HCID 58714389, compound

HRID 1241907Notes

Reaction equation

HRID 1241907 reaction equation
FC(F)(F)C(O)=O.C(OC([N:15]1[C@H:24]([C:25]([NH:27][C:28]2[CH:29]=[C:30]([C:34]3[N:35]=[C:36]([S:39][CH2:40][C:41]([NH:43][CH:44]4[CH2:49][CH2:48][N:47]([CH2:50][C:51]5[CH:56]=[CH:55][C:54]([Cl:57])=[C:53]([Cl:58])[CH:52]=5)[CH2:46][CH2:45]4)=[O:42])[S:37][CH:38]=3)[CH:31]=[CH:32][CH:33]=2)=[O:26])[CH2:23][C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH2:16]1)=O)(C)(C)C>C(Cl)(Cl)Cl>[Cl:58][C:53]1[CH:52]=[C:51]([CH:56]=[CH:55][C:54]=1[Cl:57])[CH2:50][N:47]1[CH2:48][CH2:49][CH:44]([NH:43][C:41](=[O:42])[CH2:40][S:39][C:36]2[S:37][CH:38]=[C:34]([C:30]3[CH:31]=[CH:32][CH:33]=[C:28]([NH:27][C:25]([C@@H:24]4[CH2:23][C:22]5[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=5)[CH2:16][NH:15]4)=[O:26])[CH:29]=3)[N:35]=2)[CH2:45][CH2:46]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 60107979HCID 60107979, compound

Product 1

HCID 58714389HCID 58714389, compoundYield 62.4%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Trifluoroacetic acid (5 mL) was added to the product (667 mg) of Example 54, and the mixture was stirred at room temperature for 1 hr. The reaction mixture was diluted with chloroform (100 mL), and the mixture was washed with 1 mol/L sodium hydroxide and saturated brine, and dried. The solvent was evaporated under reduced pressure to give the title compound (362 mg) as a white amorphous solid.

Workup

  1. washthe mixture was washed with 1 mol/L sodium hydroxide and saturated brine
  2. customdried
  3. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-67c499ea8cfd4111b57e7220a3b4e05d
Source dataset
uspto-grants-2006_10
Patent number
US07115635B2

Reaction notes

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