Oxalyl chloride → HCID 21935833, compound

HRID 1242447Notes

Reaction equation

HRID 1242447 reaction equation
[F:1][C:2]([F:24])([F:23])[O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:15]=[C:14]([C:16]([F:19])([F:18])[F:17])[C:13]([C:20](O)=[O:21])=[CH:12][N:11]=2)=[CH:6][CH:5]=1.C(Cl)(=O)C([Cl:28])=O>ClCCl.CN(C=O)C>[F:1][C:2]([F:24])([F:23])[O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:15]=[C:14]([C:16]([F:19])([F:18])[F:17])[C:13]([C:20]([Cl:28])=[O:21])=[CH:12][N:11]=2)=[CH:6][CH:5]=1

Participants

5

Reactant 2

HCID 65578Oxalyl chlorideHCID 21935765HCID 21935765, compound

Product 1

HCID 21935833HCID 21935833, compoundYield 99.5%

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideCatalystHCID 6344DichloromethaneSolvent

Procedure

A solution of 0.43 g (1.22 mmol) of 2-(4-trifluoromethoxy-phenyl)-4-trifluoromethyl-pyrimidine-5-carboxylic acid in 8 ml of dichloromethane was treated at RT with 2 drops of DMF. 0.12 ml (1.34 mmol, 1.1 eq) of oxalyl chloride were added within 5 min and stirring was continued for 2 h. The solution was evaporated and dried under reduced pressure to give 0.45 g of the title compound.

Workup

  1. customThe solution was evaporated
  2. customdried under reduced pressure

Sources & evidence

ORD record
ord-eb8cc6d24a794bf2b78ab535f508efe3
Source dataset
uspto-grants-2006_10
Patent number
US07115611B2

Reaction notes

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