反应详情

445 mg (0.889 mmol) of 2-{4-[4-cyclopropyl-2-(4-trifluoromethyl-phenyl)-pyrimidin-5-ylmethoxy]-phenoxy}-2-methyl-propionic acid ethyl ester and 2.7 ml 1N LiOH in 5 ml tetrahydrofurane were stirred at 50° C. over night. The reaction mixture was taken up in ether and washed with 1N HCl and water. The crude product was suspended with AcOEt/heptane 1:19. The resulting crystals were filtered off providing 393 mg pure 2-{4-[4-cyclopropyl-2-(4-trifluoromethyl-phenyl)-pyrimidin-5-ylmethoxy]-phenoxy}-2-methyl-propionic acid.

1. washwashed with 1N HCl and water
2. filtrationThe resulting crystals were filtered off