Trifluoroacetic acid → 116174-33-5

HRID 1242676Notes

Reaction equation

HRID 1242676 reaction equation
[CH3:1][S:2][C:3]1[CH:8]=[CH:7][C:6]([C:9](=O)[CH2:10][CH2:11][C:12]([OH:14])=[O:13])=[CH:5][CH:4]=1.FC(F)(F)C(O)=O.[H-].C([SiH](CC)CC)C>>[CH3:1][S:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:9][CH2:10][CH2:11][C:12]([OH:14])=[O:13])=[CH:7][CH:8]=1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 20637154-[4-(methylthio)phenyl]-4-oxobutanoic acidHCID 131724811HCID 131724811, compound

Product 1

HCID 21916663116174-33-5

Procedure

A solution of the acid obtained in Step A (19.8 g, 88.1 mmol) in trifluoroacetic acid (68 ml, 881 mmol) is brought to 0° C. and then triethylsilane hydride (35.2 ml, 220 mmol) is added dropwise using a dropping funnel. Stirring is carried out at ambient temperature for 17 hours.

Workup

  1. customis brought to 0° C.

Sources & evidence

ORD record
ord-7df6ca34d0864e24b2e68b42a93891e0
Source dataset
uspto-grants-2006_10
Patent number
US07115752B2

Reaction notes

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